tailieunhanh - Báo cáo y học: "Saponin accumulation in the seedling root of Panax notoginseng"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Saponin accumulation in the seedling root of Panax notoginseng. | Wang et al. Chinese Medicine 2011 6 5 http content 6 1 5 CHINESE MEDICINE RESEARCH Open Access Saponin accumulation in the seedling root of Panax notoginseng Dong Wang Hongtao Zhu Keke Chen Min Xu Yingjun Zhang Chongren Yang Abstract Background Panax notoginseng is an important Chinese medicinal plant. Dammarene-type triterpenoid saponins are main pharmacologically effective compounds in P. notoginseng. This study aims to investigate the formation and accumulation of saponins in P. notoginseng roots during germination and juvenile stage. Methods P. notoginseng seeds were collected and stored in wet sand. After germination the seedlings were transplanted into a soil nursery bed and cultivated for one year. During this period samples were collected every month and the concentrations of ginsengnosides Rg1 Re Rb1 Rd and notoginsengnoside R1 were determined by HPLC. Results There was little saponin in the P. notoginseng seed. The chemical composition of seed was different from that of root. After germination Rb1 Rg1 Re Rd and R1 appeared successively in the seedling root. And in the five-month-old root all these five main saponins came into existence. The accumulation of saponins in P. notoginseng root was affected by seasons. Conclusion The accumulation of saponins showed a time-dependent increase after germination of P. notoginseng. Background Panax notoginseng Burk. F. H. Chen. Sanqi a species belonging to the Araliaceae family is an important medicinal plant for its haemostatic and restorative properties 1 . Much chemical and pharmacological research on P. notoginseng has been carried out indicating that dammarene-type triterpenoid saponins are not only the main chemical components but also the main pharmacologically effective components. They exert various effects on the cardiocerebral vascular system central nervous system and endocrine system 2-7 . To date over 70 dammarene-type triterpenoid saponins have been isolated from the whole plant of P.