tailieunhanh - Báo cáo y học: " Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture. | Chung et al. Chinese Medicine 2011 6 3 http content 6 1 3 CHINESE MEDICINE RESEARCH Open Access Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture Wai Yeung Chung1 2 Hong Qi Zhang 1 Shi Ping Zhang1 Abstract Background The cholinergic and opioid systems play important roles in modulating inflammation. This study tests whether auricular acupuncture AA produces anti-inflammatory effects via opioid and peripheral cholinergic receptors in a rat model. Methods Rats were anesthetized with chloral hydrate and inflammation was induced by intraplantar injection of carrageenan. Electroacupuncture was performed at auricular points bilaterally. The severity of inflammation was assessed using changes in paw volume and thermal and mechanical pain thresholds of the rats during recovery from anesthesia. Results Electroacupuncture at selected auricular acupoints significantly reduced paw edema and mechanical hyperalgesia with no significant effect on thermal hyperalgesia. The anti-edematous and analgesic effects of AA were abolished by blockade of peripheral cholinergic muscarinic receptors with methyl atropine. Blockade of local muscarinic receptors at the inflamed site with a small dose of atropine also antagonized the anti-edematous effect of AA. By contrast systemic opioid receptor blockade with naloxone did not antagonize the anti-inflammatory effects of AA. Conclusion This study discovers a role of peripheral muscarinic receptors in mediating the anti-inflammatory effects of AA. The cholinergic muscarinic mechanism appears to be more important than the opioid mechanism in the anti-inflammatory action of AA. Background Auricular acupuncture AA has been used for a wide varieties of pain conditions such as cancer pain 1 chronic spinal pain 2 3 phantom limb pain 4 postoperative pain 5 and wound care in patients with burns 6 . Unlike body acupuncture which has been widely studied for its analgesic mechanisms 7 the .