tailieunhanh - báo cáo khoa học: " Efficacy of pharmacotherapies for short-term smoking abstinance: A systematic review and meta-analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Efficacy of pharmacotherapies for short-term smoking abstinance: A systematic review and meta-analysis | Harm Reduction Journal BioMed Central Research Efficacy of pharmacotherapies for short-term smoking abstinance A systematic review and meta-analysis Edward J Mills 1 Ping Wu2 Dean Spurden3 Jon O Ebbert4 and Kumanan Wilson5 Open Access Address faculty of Health Sciences Simon Fraser University Burnaby Canada 2Department of Epidemiology LSHTM UK 3Pfizer Limited Tadworth UK 4Mayo Clinic College of Medicine Rochester USA and 5Department of Medicine Ottawa Hospital Research Institute Ottawa Canada Email Edward J Mills - emills@ Ping Wu - pwu@ Dean Spurden - Jon O Ebbert - Kumanan Wilson - kwilson@ Corresponding author Published 18 September 2009 Received 3 February 2009 Accepted 18 September 2009 Harm Reduction Journal 2009 6 25 doi l477-75l7-6-25 This article is available from http content 6 l 25 2009 Mills et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Smoking cessation has important immediate health benefits. The comparative shortterm effectiveness of smoking cessation interventions is not well known. We aimed to determine the relative effectiveness of nicotine replacement therapy NRT bupropion and varenicline at 4 weeks post-target quit date. Methods We searched 10 electronic medical databases inception to October 2008 . We selected randomized clinical trials RCTs evaluating interventions for our primary outcome of abstinence from smoking at at-least 4 weeks post-target quit date with biochemical confirmation. We conducted random-effects odds ratio OR meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and calculated indirect comparisons. .