tailieunhanh - Báo cáo y học: "Anti-cancer natural products isolated from chinese medicinal herbs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-cancer natural products isolated from chinese medicinal herbs. | Tan et al. Chinese Medicine 2011 6 27 http content 6 1 27 CHINESE MEDICINE REVIEW Open Access Anti-cancer natural products isolated from Chinese medicinal herbs Wen Tan Jinjian Lu Mingqing Huang Yingbo Li Meiwan Chen Guosheng Wu Jian Gong Zhangfeng Zhong1 2 Zengtao Xu1 2 Yuanye Dang1 2 Jiajie Guo1 2 Xiuping Chen1 2 and Yitao Wang1 2 Abstract In recent years a number of natural products isolated from Chinese herbs have been found to inhibit proliferation induce apoptosis suppress angiogenesis retard metastasis and enhance chemotherapy exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials including flavonoids gambogic acid curcumin wogonin and silibinin alkaloids berberine terpenes artemisinin p-elemene oridonin triptolide and ursolic acid quinones shikonin and emodin and saponins ginsenoside Rg3 which are isolated from Chinese medicinal herbs. In particular the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed. Background Surgery chemotherapy and radiotherapy are the main conventional cancer treatment often supplemented by other complementary and alternative therapies in China 1 . While chemotherapy is one of the most extensively studied methods in anti-cancer therapies its efficacy and safety remain a primary concern as toxicity and other side effects of chemotherapy are severe. Moreover multi-drug resistant cancer is even a bigger challenge. Medicinal herbs are main sources of new drugs. Newman et al. reported that more than half of the new chemicals approved between 1982 and 2002 were derived directly or indirectly from natural products 2 . Some active compounds have been isolated from Chinese medicinal herbs and tested for .