tailieunhanh - Báo cáo y học: " Exhaled nitric oxide and urinary EPX levels in infants: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Exhaled nitric oxide and urinary EPX levels in infants: a pilot study. | Carlstedt et al. Clinical and Molecular Allergy 2011 9 8 http content 9 1 8 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access Exhaled nitric oxide and urinary EPX levels in infants a pilot study Fredrik Carlstedt 1 Dagmara Lazowska1 Carl-Gustaf Bornehag2 Anna-Carin Olin3 and Mikael Hasselgren1 4 Abstract Background Objective markers of early airway inflammation in infants are not established but are of great interest in a scientific setting. Exhaled nitric oxide FeNO and urinary eosinophilic protein X uEPX are a two such interesting markers. Objective To investigate the feasibility of measuring FeNO and uEPX in infants and their mothers and to determine if any relations between these two variables and environmental factors can be seen in a small sample size. This was conducted as a pilot study for the ongoing Swedish Environmental Longitudinal Mother and child Asthma and allergy study SELMA . Methods Consecutive infants between two and six months old and their mothers at children s health care centres were invited and 110 mother-infant pairs participated. FeNO and uEPX were analysed in both mothers and infants. FeNO was analyzed in the mothers online by the use of the handheld Niox Mino device and in the infants offline from exhaled air sampled during tidal breathing. A 33-question multiple-choice questionnaire that dealt with symptoms of allergic disease heredity and housing characteristics was used. Results FeNO levels were reduced in infants with a history of upper respiratory symptoms during the previous two weeks p . There was a trend towards higher FeNO levels in infants with windowpane condensation in the home p . There was no association between uEPX in the infants and the other studied variables. Conclusion The use of uEPX as a marker of early inflammation was not supported. FeNO levels in infants were associated to windowpane condensation. Measuring FeNO by the present method may be an interesting way of .