tailieunhanh - Báo cáo khoa học: RIP1 comes back to life as a cell death regulator in TNFR1 signaling

Cell death induction by tumor necrosis factor has been an intensively stud-ied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now, new secrets about tumor necrosis factor death signaling are still being uncovered. | IFEBS Journal MINIREVIEW RIP1 comes back to life as a cell death regulator in TNFR1 signaling Marie Anne O Donnell and Adrian T. Ting Immunology Institute Mount Sinai Schoolof Medicine New York USA Keywords apoptosis caspase IAP necrosis NEMO NF-kB RIP TNF TRAF ubiquitin Correspondence M. A. O Donnell Immunology Institute Mount Sinai Schoolof Medicine Box 1630 One Gustave L. Levy Place New York NY 10029 USA Fax 1 212 849 2525 Tel 1 212 659 9417 E-mail Cell death induction by tumor necrosis factor has been an intensively studied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now new secrets about tumor necrosis factor death signaling are still being uncovered. In particular the recent evidence that ubiquitination of the death kinase receptor-interacting protein 1 regulates its participation in apoptotic and necrotic cell death is opening up unexplored avenues in the catacombs of tumor necrosis factor death signaling. In this minireview we focus on two major cell-death checkpoints that determine whether receptor-interacting protein 1 functions as a pro-survival or pro-death molecule. Received 12 October 2010 revised 8 December 2010 accepted 13 December 2010 doi Introduction The cytokine tumor necrosis factor TNF can communicate a diverse array of inflammatory and immune gene expression programs by activating different transcription factors. TNF signaling can be translated into two opposing cell fate outcomes cell survival or cell demise. The signaling complexes that prolong cell life or instigate cell death often form simultaneously within a single cell type. A central problem in TNF signaling has been to find out what bestows TNF with this antagonymic quality what determines life versus death One of the earliest observations in the TNF signaling field was that most cell types do not die when treated with TNF. However TNF treatment could provoke .