tailieunhanh - Báo cáo y học: " Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. | Bunyavanich et al. Clinical and Molecular Allergy 2011 9 1 http content 9 1 1 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access Thymic stromal lymphopoietin TSLP is associated with allergic rhinitis in children with asthma Cl I I I Di I k k kk G h 1 2 5E r 11 h IS-. IS-. 1 5 6 7 IW-I w-i D A ỉ I I 9 h ỉ k s r I 10 h ỉ I I r I E C hi 11 k r r- 12 Supinda Bunyavanich triK Meien Jemma B WilK Mark Granada Manuel t Soto-Quiros Lydiana Avila12 Jessica LasKy-Su1 5 Gary M HunninghaKe1 3 5 Magnus Wickman6 8 Goran Pershagen6 George T O Connor10 11 Scott T Weiss1 4 5 Juan C Celedon1 3 4 5 13 14 15 Abstract Background Allergic rhinitis AR affects up to 80 of children with asthma and increases asthma severity. Thymic stromal lymphopoietin TSLP is a Key mediator of allergic inflammation. The role of the TSLP gene TSLP in the pathogenesis of AR has not been studied. Objective To test for associations between variants in TSLP TSLP-related genes and AR in children with asthma. Methods We genotyped 15 single nucleotide polymorphisms SNPs in TSLP OX40L IL7R and RXRa in three independent cohorts 592 asthmatic Costa Rican children and their parents 422 nuclear families of North American children with asthma and 239 Swedish children with asthma. We tested for associations between these SNPs and AR. As we previously reported sex-specific effects for TSLP we performed overall and sex-stratified analyses. We additionally performed secondary analyses for gene-by-gene interactions. Results Across the three cohorts the T allele of TSLP SNP rs1837253 was undertransmitted in boys with AR and asthma as compared to boys with asthma alone. The SNP was associated with reduced odds for AR odds ratios ranging from to with corresponding Fisher s combined P value of X 10-4 . Our findings were significant after accounting for multiple comparisons. SNPs in OX40L IL7R and RXRa were not consistently associated with AR in children with asthma. There were