tailieunhanh - Báo cáo y học: "Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma. | Chang et al. Clinical and Molecular Allergy 2010 8 11 http content 8 1 11 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma 1 11 2 2 2 Carolyn Chang Kevin Gauvey-Kern Alina Johnson Elizabeth A Kelvin Ginger L Chew Frederica Perera Rachel L Miller1 2 3 Abstract Background Fetal immune responses following exposure of mothers to allergens during pregnancy may influence the subsequent risk of childhood asthma. However the association of allergen-induced cord blood mononuclear cell CBMC proliferation and cytokine production with later allergic immune responses and asthma has been controversial. Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell PBMC proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort. Methods As part of an ongoing cohort study of the Columbia Center for Children s Environmental Health CCCEH CBMCs and age 5 PBMCs were cultured with cockroach mouse and dust mite protein extracts. CBMC proliferation and cytokine IL-5 and IFN-y responses and age 5 PBMC proliferation responses were compared to anti-cockroach anti-mouse and anti-dust mite IgE levels wheeze cough eczema and asthma. Results Correlations between CBMC and age 5 PBMC proliferation in response to cockroach mouse and dust mite antigens were nonsignificant. Cockroach- mouse- and dust mite-induced CBMC proliferation and cytokine responses were not associated with allergen-specific IgE at ages 2 3 and 5 or with asthma and eczema at age 5. However after adjusting for potential confounders age 5 cockroach-induced PBMC proliferation was associated with anti-cockroach IgE total IgE and asthma p . Conclusion In contrast to allergen-induced CBMC proliferation age 5 cockroach-induced PBMC proliferation was associated with age 5 specific and total IgE and asthma in an .