tailieunhanh - Báo cáo y học: "IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring. | Matson et al. Clinical and Molecular Allergy 2010 8 9 http content 8 1 9 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring Adam P Matson 1 2 Roger S Thrall1 Ektor Raft 1 3 Elizabeth G Lingenheld1 and Lynn Puddington 1 Abstract Background The mechanism s responsible for the reduced risk of allergic disease in breastfed infants are not fully understood. Using an established murine model of asthma we demonstrated previously that resistance to allergic airway disease transmitted from allergic mothers to breastfed offspring requires maternal B cell-derived factors. Objective The aim of this study was to investigate the role of offspring neonatal Fc receptor for IgG uptake by intestinal epithelial cells FcRn in this breast milk transferred protection from allergy. Methods Allergic airway disease was induced during pregnancy in C57BL 6 female mice. These allergic mothers foster nursed naive FcRn - or FcRn- - progeny born to FcRn - females that were mated to C57BL 6J-FcRn- - male mice. In offspring deficient in FcRn we expected reduced levels of systemic allergen-specific IgG1 a consequence of decreased absorption of maternal IgG from the lumen of the neonatal gastrointestinal tract. Using this model we were able to investigate how breast milk IgG affected offspring responses to allergic sensitization. Results Levels of maternal antibodies absorbed from the breast milk of allergic foster mothers were determined in weanling FcRn-sufficient or -deficient mice. Maternal transmission of allergen-specific IgG1 to breastfed FcRn- - offspring was at levels 103-104 lower than observed in FcRn - or FcRn mice. Five weeks after weaning when offspring were 8 wk old mice were sensitized and challenged to evaluate their susceptibility to develop allergic airway disease. Protection indicated by reduced parameters of disease allergen-specific IgE in serum .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.