tailieunhanh - Báo cáo y học: "Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy. | Rossi et al. Clinical and Molecular Allergy 2010 8 4 http content 8 1 4 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy Renato E Rossi 1 Giorgio Monasterolo2 Cristoforo Incorvaia3 Philippe Moingeon4 Franco Frati5 Giovanni Passalacqua6 Lucilla Rossi7 and Giorgio W Canonica6 Abstract Background Some studies reported the possible induction of food allergy caused by neo-sensitization to crossreacting allergens during immunotherapy with aeroallergens while other studies ruled out such possibility. Objectives The aim of this study was to evaluate the development of neo-sensitization to Pen a 1 tropomyosin as well as the appearance of reactions after ingestion of foods containing tropomyosin as a consequence of sublingual mite immunization. Materials and methods Specific IgE to Tropomyosin rPen a 1 before and after mite sublingual immunotherapy in 134 subjects were measured. IgE-specific antibodies for mite extract and recombinant allergen Pen a 1 were evaluated using the immunoenzymatic CAP system Phadia Diagnostics Milan Italy . Results All patients had rPen a 1 IgE negative results before and after mite SLIT and did not show positive shrimp extract skin reactivity and serological rPen a 1 IgE conversion after treatment. More important no patient showed systemic reactions to crustacean ingestion. Conclusions Patients did not show neo-sensitization to tropomyosin a component of the extract namely mite group 10 administered. An assessment of a patient s possible pre-existing sensitisation to tropomyosin by skin test and or specific IgE prior to start mite extract immunotherapy is recommended. Trial Registration This trial is registered in EudraCT with the ID number of 2010-02035531. Introduction In developed countries respiratory allergy is an important cause of chronic illness 1 and has a significant socio-economic impact 2 . As stated in .