tailieunhanh - Báo cáo y học: "Genetics of asthma: a molecular biologist perspective"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genetics of asthma: a molecular biologist perspective. | Clinical and Molecular Allergy BioMed Central Open Access Genetics of asthma a molecular biologist perspective Amrendra Kumar and Balaram Ghosh Address Molecular Immunogenetics Laboratory Institute of Genomics and Integrative Biology Mall Road Delhi-110007 India Email Amrendra Kumar - amrendragupta@ Balaram Ghosh - bghosh@ Corresponding author Published 6 May 2009 Received 20 December 2008 Clinical and Molecular Allergy 2009 7 7 doi 1476-7961-7-7 Accepted 6 May 2009 This article is available from http content 7 1 7 2009 Kumar and Ghosh licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as disease of civilizations . Due to its increased prevalence among related individuals it was understood quite long back that it is a genetic disorder. Well designed epidemiological studies reinforced these views. The advent of modern biological technology saw further refinements in our understanding of genetics of asthma and led to the realization that asthma is not a disorder with simple Mendelian mode of inheritance but a multifactorial disorder of the airways brought about by complex interaction between genetic and environmental factors. Current asthma research has witnessed evidences that are compelling researchers to redefine asthma altogether. Although no consensus exists among workers regarding its definition it seems obvious that several pathologies all affecting the airways have been clubbed into one common category called .