tailieunhanh - Báo cáo y học: "Three dimensional structure directs T-cell epitope dominance associated with allergy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Three dimensional structure directs T-cell epitope dominance associated with allergy. | Clinical and Molecular Allergy BioMed Central Research Three dimensional structure directs T-cell epitope dominance associated with allergy Scott J Melton 1 and Samuel J Landry2 Open Access Address biomedical Sciences Graduate Program Tulane University Health Sciences Center New Orleans LA 70112 USA and 2Department of Biochemistry Tulane University Health Sciences Center New Orleans LA 70112 USA Email Scott J Melton - smelton@ Samuel J Landry - landry@ Corresponding author Published 15 September 2008 Received 6 February 2008 . n .1 -rn Accepted 15 September 2008 Clinical and Molecular Allergy 2008 6 9 doi l476-796l-6-9 This article is available from http content 6 l 9 2008 Melton and Landry licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background CD4 T-cell epitope immunodominance is not adequately explained by peptide selectivity in class II major histocompatibility proteins but it has been correlated with adjacent segments of conformational flexibility in several antigens. Methods The published T-cell responses to two venom allergens and two aeroallergens were used to construct profiles of epitope dominance which were correlated with the distribution of conformational flexibility as measured by crystallographic B factors solvent-accessible surface COREX residue stability and sequence entropy. Results Epitopes associated with allergy tended to be excluded from and lie adjacent to flexible segments of the allergen. Conclusion During the initiation of allergy the N- and or C-terminal ends of proteolytic processing intermediates were preferentially loaded into .