tailieunhanh - Báo cáo khoa học: miRNAs and regulation of cell signaling

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding to target mRNAs in a sequence-specific manner. A large number of genes appear to be the target of miRNAs, and an essential role for miRNAs in the regulation of various conserved cell signaling cascades, such as mitogen-activated protein kinase, Notch and Hedgehog | ịFEBS Journal MINIREVIEW miRNAs and regulation of cell signaling Atsuhiko Ichimura Yoshinao Ruike Kazuya Terasawa and Gozoh Tsujimoto Department of Genomic Drug Discovery Science Graduate Schoolof PharmaceuticalSciences Kyoto University Japan Keywords cell signaling feedback regulation miRNAs regulatory network signal cascades Correspondence G. Tsujimoto Department of Genomic Drug Discovery Science Graduate School of PharmaceuticalSciences Kyoto University 46-29 Yoshida Shimoadachi-cho Sakyo-ku Kyoto 606-8501 Japan Fax 81 75 753 4544 Tel 81 75 753 4523 E-mail gtsuji@ MicroRNAs miRNAs regulate gene expression post-transcriptionally by binding to target mRNAs in a sequence-specific manner. A large number of genes appear to be the target of miRNAs and an essential role for miRNAs in the regulation of various conserved cell signaling cascades such as mitogen-activated protein kinase Notch and Hedgehog is emerging. Extensive studies have also revealed the spatial and temporal regulation of miRNA expression by various cell signaling cascades. The insights gained in such studies support the idea that miRNAs are involved in the highly complex network of cell signaling pathways. In this minireview we present an overview of these complex networks by providing examples of recent findings. Received 10 November 2010 revised 6 February 2011 accepted 1 March 2011 doi Introduction In higher organisms the regulation of the transcriptome is extremely complicated. Traditionally regulation of the transcriptome referred mainly to the activation or repression of gene expression by transcription factors. However gene expression in higher organisms is now known to be controlled by a multilayered regulatory network that includes epigenetic modification of the genome and post-translational modification of gene products. The discovery of microRNAs miRNAs which regulate gene expression post-transcriptionally has added to the complexity of .