tailieunhanh - Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms

The cardiac hormones atrial natriuretic peptide and B-type natriuretic pep-tide (brain natriuretic peptide) activate guanylyl cyclase (GC)-A⁄natriuretic peptide receptor-A (NPRA) and produce the second messenger cGMP. GC-A⁄NPRA is a member of the growing family of GC receptors. | FEBS Journal MINIREVIEW The functional genomics of guanylyl cyclase natriuretic peptide receptor-A Perspectives and paradigms Kailash N. Pandey Department of Physiology Tulane University Health Sciences Center Schoolof Medicine New Orleans LA USA Keywords cardiac hypertrophy functional genomics guanylylcyclase receptor hypertension natriuretic peptides Correspondence K. N. Pandey Department of Physiology SL 39 Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA 70112 USA Fax 1 504 9882675 Tel 1 504 988 1628 E-mail kpandey@ Received 2 September 2010 revised 7 December 2010 accepted 2 March 2011 doi The cardiac hormones atrial natriuretic peptide and B-type natriuretic peptide brain natriuretic peptide activate guanylyl cyclase GC -A natriuretic peptide receptor-A NPRA and produce the second messenger cGMP. GC-A NPRA is a member of the growing family of GC receptors. The recent biochemical molecular and genomic studies on GC-A NPRA have provided important insights into the regulation and functional activity of this receptor protein with a particular emphasis on cardiac and renal protective roles in hypertension and cardiovascular disease states. The progress in this field of research has significantly strengthened and advanced our knowledge about the critical roles of Npr1 coding for GC-A NPRA in the control of fluid volume blood pressure cardiac remodeling and other physiological functions and pathological states. Overall this review attempts to provide insights and to delineate the current concepts in the field of functional genomics and signaling of GC-A NPRA in hypertension and cardiovascular disease states at the molecular level. Introduction The initial work by de Bold et al. 1 established that atrial extracts contained natriuretic and diuretic activities and demonstrated the existence of atrial natriuretic factor atrial natriuretic peptide ANP . Members of a family of endogenous peptide .