tailieunhanh - báo cáo khoa học: " US smokers’ reactions to a brief trial of oral nicotine products"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: US smokers’ reactions to a brief trial of oral nicotine products | O Connor et al. Harm Reduction Journal 2011 8 1 http content 8 1 1 HARM REDUCTION JOURNAL RESEARCH Open Access US smokers reactions to a brief trial of oral nicotine products 1 1 1 1 2 Richard J O Connor Kaila J Norton Maansi Bansal-Travers Martin C Mahoney K Michael Cummings Ron Borland2 Abstract Background It has been suggested that cigarette smokers will switch to alternative oral nicotine delivery products to reduce their health risks if informed of the relative risk difference. However it is important to assess how smokers are likely to use cigarette alternatives before making predictions about their potential to promote individual or population harm reduction. Objectives This study examines smokers interest in using a smokeless tobacco or a nicotine replacement product as a substitute for their cigarettes. Methods The study included 67 adult cigarette smokers not currently interested in quitting who were given an opportunity to sample four alternative oral nicotine products 1 Camel Snus 2 Marlboro Snus 3 Stonewall dissolvable tobacco tablets and 4 Commit nicotine lozenges. At visit 1 subjects were presented information about the relative benefits risks of oral nicotine delivery compared to cigarettes. At visit 2 subjects were given a supply of each of the four products to sample at home for a week. At visit 3 subjects received a one-week supply of their preferred product to see if using such products reduced or eliminated cigarette use. Results After multiple product sampling participants preferred the Commit lozenges over the three smokeless tobacco products p . Following the one week single-product trial experience GEE models controlling for gender age level of education baseline cigarettes use and alternative product chosen indicated a significant decline in cigarettes smoked per day across one week of single-product sampling p from to cigarettes per day but no change in alternative product use approximately