tailieunhanh - báo cáo khoa học: " Increased risk for hepatitis C associated with solvent use among Canadian Aboriginal injection drug users"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Increased risk for hepatitis C associated with solvent use among Canadian Aboriginal injection drug users | Shaw et al. Harm Reduction Journal 2010 7 16 http content 7 1 16 HARM REDUCTION JOURNAL RESEARCH Open Access Increased risk for hepatitis C associated with solvent use among Canadian Aboriginal injection drug users Souradet Y Shaw 1 2 Kathleen N Deering3 Ann M Jolly4 5 and John L Wylie2 6 7 Abstract Background Solvent abuse is a particularly serious issue affecting Aboriginal people. Here we examine the association between solvent use and socio-demographic variables drug-related risk factors and pathogen prevalence in Aboriginal injection drug users IDU in Manitoba Canada. Methods Data originated from a cross-sectional survey of IDU from December 2003 to September 2004. Associations between solvent use and variables of interest were assessed by multiple logistic regression. Results A total of 266 Aboriginal IDU were included in the analysis of which 44 self-reported recent solvent use. Hepatitis C infection was 81 in solvent-users compared to 55 in those reporting no solvent use. In multivariable models solvent-users were younger and more likely to be infected with hepatitis C AOR 95 CI to have shared needles in the last six months AOR 95 CI and to have injected talwin Ritalin AOR 95 CI . Interpretation High hepatitis C prevalence even after controlling for risky injection practices suggests that solvent users may form closed networks of higher risk even amongst an already high-risk IDU population. Understanding the social-epidemiological context of initiation and maintenance of solvent use is necessary to address the inherent inequalities encountered by this subpopulation of substance users and may inform prevention strategies for other marginalized populations. Background In developed countries sexually transmitted infections STI and bloodborne pathogens BBP disproportionately affect marginalized populations. In the United States Australia and Canada the combined impact of poverty lack of access