tailieunhanh - Structural Approaches to Sequence Evolution Molecules, Networks, Populations

Soon after the first sequences of proteins and nucleic acids became available for comparative analysis, it became apparent that they can play a key role for reconstructing the evolution of life. The availability of the sequence of several proteins prompted the birth of the field of molecular evolution, which aims at both the reconstruction of the biochemical history of life and the understanding of the mechanisms of evolution at the molecular level through the analysis of the macromolecules of existing organisms. These ambitious goals can only be accomplished within a wide interdisciplinary approach that combines together experimental techniques of molecular biology, bioinformatics and mathematical modeling. Indeed, the huge amount. | Ugo Bastolla Markus Porto H. Eduardo Roman Michele Vendruscolo Editors BIOLOGICAL AND MEDICAL PHYSICS BIOMEDICAL ENGINEERING Structural Approaches to Sequence Evolution M 7 1 I HMWf TO Molecules Networks Populations Í p. J rủi V ĩ ĨÍ . Ỉ Bo 0 Springer biological and medical physics biomedical engineering biological and medical physics biomedical engineering The fields of biological and medical physics and biomedical engineering are broad multidisciplinary and dynamic. They lie at the crossroads of frontier research in physics biology chemistry and medicine. The Biological and Medical Physics Biomedical Engineering Series is intended to be comprehensive covering a broad range of topics important to the study of the physical chemical and biological sciences. Its goal is to provide scientists and engineers with textbooks monographs and reference works to address the growing need for information. Books in the series emphasize established and emergent areas of science including molecular membrane and mathematical biophysics photosynthetic energy harvesting and conversion information processing physical principles of genetics sensory communications automata networks neural networks and cellular automata. Equally important will be coverage of applied aspects of biological and medical physics and biomedical engineering such as molecular electronic components and devices biosensors medicine imaging physical principles of renewable energy production advanced prostheses and environmental control and engineering. Editor-in-Chief Elias Greenbaum Oak Ridge National Laboratory Oak Ridge Tennessee USA Editorial Board Masuo Aizawa Department of Bioengineering Tokyo Institute of Technology Yokohama Japan Olaf S. Andersen Department of Physiology Biophysics Molecular Medicine Cornell University New York USA Robert H. Austin Department of Physics Princeton University Princeton New Jersey USA James Barber Department of Biochemistry Imperial College of Science Technology and .