tailieunhanh - Báo cáo y học: " Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patients. | Comparative Hepatology BioMed Central Research Open Access Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naive genotype I patients Denis Ouzan1 Hacène Khiri2 Guillaume Pénaranda 3 Hélène Joly1 and Philippe Halfon2 Address 1Arnault Tzanck Institut Saint Laurent du Var France 2Virological Department Alphabio Laboratory Marseille France and 3Biostatistics and Epidemiology Department CDLPharma Marseille France Email Denis Ouzan - Hacène Khiri - Guillaume Pénaranda - Hélène Joly - Philippe Halfon - Corresponding author Published 21 December 2005 Received 24 May 2005 Accepted 21 December 2005 Comparative Hepatology 2005 4 9 doi l476-5926-4-9 r This article is available from http content 4 1 9 2005 Ouzan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pegylated interferon given for 24 or 48 weeks constitutes the most effective initial therapy for the treatment of chronic hepatitis C. It has been shown that viral load at week 2 appears the best time for predicting response to treatment. The objectives of this study were to assess whether the hepatitis C virus HCV RNA viral decline is predictive of sustained virological response SVR and to determine the best time for predicting complete response in our cohort of naive patients treated with pegylated interferon alpha-2a Peg-IFN alpha-2a and ribavirin. Results Twenty patients treated with Peg-IFN alpha-2a and ribavirin for 48 weeks were studied. Six months after the end of treatment a SVR negative HCV RNA measured by PCR six months after the end .