tailieunhanh - Báo cáo y học: " A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation. | Comparative Hepatology BioMed Central Research Open Access A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids in early systemic inflammation Christian Wunder 1 Robert W Brock3 Alfons Krug2 Norbert Roewer1 and Otto Eichelbronner1 Address 1Klinik und Poliklinik fur Anasthesiologie Julius-Maximilians-Universitat Wurzburg Zentrum fur Operative Medizin Oberdurrbacher Strasse 6 97080 Wurzburg Germany 2LEA Medizintechnik GmbH 35394 Giessen Germany and 3Department of Pharmacology Toxicology University of Arkansas for Medical Sciences 72205-7199 Little Rock USA Email Christian Wunder - Robert W Brock - BrockRobertW@ Alfons Krug - krug@ Norbert Roewer - Otto Eichelbronner - oeichelbroenner@ Corresponding author Published 12 January 2005 Received 20 October 2004 Accepted 12 January 2005 Comparative Hepatology 2005 4 1 doi 86 1476-5926-4-1 This article is available from http content 4 1 1 2005 Wunder et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background During the early stages of systemic inflammation the liver integrity is compromised by microcirculatory disturbances and subsequent hepatocellular injury. Little is known about the relationship between the hemoglobin oxygen saturation HbsO2 in sinusoids and the hepatocellular mitochondrial redox state in early systemic inflammation. In a murine model of early systemic inflammation we have explored the association between the sinusoidal HbsO2 detected with a remission spectroscopy system and 1. the NAD P H autofluorescence an indicator of the .