tailieunhanh - Báo cáo y học: "The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo. | Comparative Hepatology BioMed Central Research Open Access The role of ATP and adenosine in the control of hepatic blood flow in the rabbit liver in vivo Dominic J Browse1 Robert T Mathie2 Irving S Benjamin1 and Barry Alexander 1 Address 1Liver Sciences Unit Academic Department of Surgery GKT School of Medicine and Dentistry St Thomas Hospital Lambeth Palace Road London SE1 7EH UK and 2Division of Surgery Imperial College School of Medicine Hammersmith Hospital 150 Du Cane Road London W12 ONN UK Email Dominic J Browse - Robert T Mathie - Irving S Benjamin - Barry Alexander - Corresponding author Published 26 November 2003 Received 15 July 2003 Accepted 26 November 2003 Comparative Hepatology 2003 2 9 This article is available from http content 2 1 9 2003 Browse et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The role of adenosine and ATP in the regulation of hepatic arterial blood flow in the buffer response was studied in vitro and in a new in vivo model in the rabbit. The model achieves portal-systemic diversion by insertion of a silicone rubber prosthesis between the portal vein and inferior vena cava and avoids alterations in systemic haemodynamics. Results Hepatic arterial HA blood flow increased in response to reduced portal venous PV blood flow the buffer response from ml min-1 100 g-1 to ml min-1 100 g-1 mean SE p Student s paired t-test . This represented a buffering capacity of . Intra-portal injections of ATP or adenosine 1 micrograms mg kg-1 elicited immediate increases in HA blood flow to give -log ED50 values of and mg kg-1 for ATP and adenosine respectively. Injection