tailieunhanh - Báo cáo y học: "Liver sinusoidal endothelial cells represents an important blood clearance system in pigs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Liver sinusoidal endothelial cells represents an important blood clearance system in pigs. | Comparative Hepatology BioMed Central Research Open Access Liver sinusoidal endothelial cells represents an important blood clearance system in pigs Geir I Nedredal 1 Kjetil H Elvevold2 Lars M Ytrebo1 Randi Olsen3 Arthur Revhaug1 and Bârd Smedsrod2 Address Department of Digestive Surgery University Hospital of Tromso 9038 Tromso Norway 2Department of Experimental Pathology Institute of Medical Biology University of Tromso 9037 Tromso Norway and 3Department of Electron Microscopy Institute of Medical Biology University of Tromso 9037 Tromso Norway Email Geir I Nedredal - Kjetil H Elvevold - Kjetilhe@ Lars M Ytrebo - Larsmy@ Randi Olsen - randio@ Arthur Revhaug - Bârd Smedsrod - baards@ Corresponding author Published 3 January 2003 Received 24 October 2002 Accepted 3 January 2003 Comparative Hepatology 2003 2 1 This article is available from http content 2 1 1 2003 Nedredal et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Numerous studies in rats and a few other mammalian species including man have shown that the sinusoidal cells constitute an important part of liver function. In the pig however which is frequently used in studies on liver transplantation and liver failure models our knowledge about the function of hepatic sinusoidal cells is scarce. We have explored the scavenger function of pig liver sinusoidal endothelial cells LSEC a cell type that in other mammals performs vital elimination of an array of waste macromolecules from the circulation. Results 125I-macromolecules known to be cleared in the rat via the scavenger and mannose receptors were rapidly removed from the pig circulation 50 of the injected dose being .