tailieunhanh - Báo cáo y học: " Apoptosis of uninfected cells induced by HIV envelope glycoproteins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Apoptosis of uninfected cells induced by HIV envelope glycoproteins | Retrovirology BioMed Central Review Apoptosis of uninfected cells induced by HIV envelope glycoproteins Barbara Ahr Véronique Robert-Hebmann Christian Devaux and Martine Biard-Piechaczyk Open Access Address Laboratoire Infections Rétrovirales et Signalisation Cellulaire CNRS UMR 5121-UM1 Institut de Biologie 4 Bd Henri IV CS 89508 34960 Montpellier Cedex 2 France Email Barbara Ahr - Véronique Robert-Hebmann - Christian Devaux- Martine Biard-Piechaczyk - Corresponding author Published 23 June 2004 Received 06 April 2004 Retrovirology 2004 1 12 doi 1742-4690-1-12 Accepted 23 June 2004 This article is available from http content 1 1 12 2004 Ahr et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Apoptosis or programmed cell death is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus HIV infection. Although multiple mechanisms contribute to the gradual T cell decline that occurs in HIV-infected patients programmed cell death of uninfected bystander T lymphocytes including CD4 and CD8 T cells is an important event leading to immunodeficiency. The HIV envelope glycoproteins Env play a crucial role in transducing this apoptotic signal after binding to its receptors the CD4 molecule and a coreceptor essentially CCR5 and CXCR4. Depending on Env presentation the receptor involved and the complexity of target cell contact apoptosis induction is related to death receptor and or mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated cell death leading to T cell depletion and clinical complications and covers the sometimes

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