tailieunhanh - Báo cáo y học: "The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? | Duffy et al. Clinical Proteomics 2011 8 9 http content 8 1 9 CLINICAL PROTEOMICS REVIEW Open Access The ADAMs family of proteases new biomarkers and therapeutic targets for cancer I Ỉ o I I Pil ifí 1 2M 2 O I I 11 l 1 2 Mnirm fi3 Cl im i n i 72 H Cl ilzAM 2 4 rfYA n4 Aiclif i 1 Diorfo1 2 fiiH Miciidei J Dully Maeve Muiiooiy iNuinid ODUHUVdn sumdinizdH sukor Joiin Ciuwn Aisiing Pierce dnd Patricia M McGowan1 2 Correspondence . duffy@ 1Depdrtment of PdtHoiogy dnd Ldbordtory Medicine St. Vincent s University Hospitdi Dubiin 4 Ireidnd Fuii iist ofdutHor informdtion is dVdiidbie dt tHe end of tHe drticie 2 BioMed Central Abstract THe ADAMs dre trdnsmembrdne proteins impiicdted in proteoiysis dnd ceii ddHesion. Forty gene members of tHe fdmiiy Hdve been identified of wHicH 21 dre beiieved to be functiondi in Humdns. As protedses tHeir mdin substrates dre tHe ectodomdins of otHer transmembrane proteins. THese substrates inciude precursor forms of growtH fdctors cytokines growtH fdctor receptors cytokine receptors dnd severdi different types of ddHesion moiecuies. AitHougH ditered expression of specific ADAMs Hds been impiicdted in different disedses tHeir best-documented roie is in cdncer formdtion dnd progression. ADAMs sHown to pidy d roie in cdncer inciude ADAM9 ADAM10 ADAM12 ADAM15 dnd ADAM17. Two of tHe ADAMs . ADAM10 dnd 17 dppedr to promote cdncer progression by reiedsing HER EGFR iigdnds. THe reiedsed iigdnds dctivdte HER EGFR signdiiing tHdt cuimindtes in incredsed ceii proiiferdtion migrdtion dnd survivdl. Consistent witH d cdusdtive role in cdncer severdl ADAMs dre emerging ds potentidi cdncer biomdrkers for diding cdncer didgnosis dnd predicting pdtient outcome. FurtHermore d number of seiective ADAM inHibitors especidiiy dgdinst ADAM10 dnd ADAM17 Hdve been sHown to Hdve dnti-cdncer effects. At ledst one of tHese inHibitors is now undergoing clinicdl tridls in pdtients witH bredst cdncer. Review The ADAMs are