tailieunhanh - Báo cáo y học: " Early steps of retrovirus replicative cycle"

Retrovirology Review Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Early steps of retrovirus replicative cycle | Retrovirology BioMed Central Review Early steps of retrovirus replicative cycle Sébastien Nisole2 and Ali Saib 1 Open Access Address 1CNRS UPR9051 Hôpital Saint-Louis 1 Avenue Claude Vellefaux 75475 Paris cedex 10 France and 2Division of Virology National Institute for Medical Research The Ridgeway Mill Hill London NW7 1AA United Kingdom Email Sébastien Nisole - snisole@ Ali Saib - alisaib@ Corresponding author Published 14 May 2004 Received 06 March 2004 Accepted 14 May 2004 Retrovirology 2004 1 9 This article is available from http content l l 9 2004 Nisole and Sai b licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract During the last two decades the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However while the late stages of the retrovirus life cycle consisting of virus replication and egress have been partly unraveled the early steps remain largely enigmatic. These early steps consist of a long and perilous journey from the cell surface to the nucleus where the proviral DNA integrates into the host genome. Retroviral particles must bind specifically to their target cells cross the plasma membrane reverse-transcribe their RNA genome while uncoating the cores find their way to the nuclear membrane and penetrate into the nucleus to finally dock and integrate into the cellular genome. Along this journey retroviruses hijack the cellular machinery while at the same time counteracting cellular defenses. Elucidating these mechanisms and identifying which cellular factors are exploited by the retroviruses and which hinder their life cycle will certainly lead to the discovery of new ways to inhibit viral replication and to improve .