tailieunhanh - Báo cáo y học: " HIV CTL escape: at what cost?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Address: Saint Michael's Medical Center and The New Jersey Medical School, Newark New J | Retrovirology BioMed Central Commentary HIV CTL escape at what cost Stephen M Smith Address Saint Michael s Medical Center and The New Jersey Medical School Newark New Jersey 07102 USA Email Stephen M Smith - ssmith1824@ Corresponding author Open Access Published 12 May 2004 Received 05 April 2004 Accepted 12 May 2004 Retrovirology 2004 1 8 This article is available from http content 1 1 8 2004 Smith licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Recent data have established the HIV-1 and SIV escape CTL through epitope mutation. However three novel studies prove that such escape comes at a cost to overall viral fitness. Understanding how HIV-1 SIV escape CTL and the impact of the escape mutations has tremendous importance in developing CTL based vaccines. Further a CTL based HIV-1 vaccine is likely to have long-term protective effect against disease only if the escape virus is significantly weakened compared with wild type. Data on humans infected with human immunodeficiency virus type 1 HIV-1 and macaques infected with simian immunodeficiency virus SIV suggest that cytotoxic T-lymphocytes CTL are important in controlling virus replication 1 . CTL target infected cells by recognizing viral peptides 8-10 residues in length bound to class I major histocompatibility complex MHC molecules. Different MHC alleles bind viral peptides with different affinities. MHC alleles which bind particular viral peptides well often result in strong cellular responses against those viral epitopes. In theory if CTL are important in controlling or reducing HIV-1 replication in vivo then virus mutants that avoid this cellular response should have a replicative advantage in the host. Indeed several studies in both macaques and humans have documented the presence of virus .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.