tailieunhanh - Báo cáo y học: " Development of Parkinsonism following exposure to aripiprazole: two case reports"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Development of Parkinsonism following exposure to aripiprazole: two case reports | JOURNAL OF MEDICAL Sr CASE REPORTS Case report Development of Parkinsonism following exposure to aripiprazole two case reports Lannah L Lua and Lin Zhang Open Access Address Department of Neurology University of California Davis School of Medicine 4860 Y Street Suite 3700 Sacramento California 95817 United States Email LL - lllua@ LZ - Corresponding author Published 10 March 2009 Received 30 December 2008 Journal of Medical Case Reports 2009 3 6448 doi I752-I947-3-6448 Accepted 9 February 2009 This article is available from http jmedicalcasereports article view 3 3 6448 2009 Lua and Zhang licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Aripiprazole is a novel atypical neuroleptic used in the treatment of psychosis. A few recent studies have demonstrated an association between the use of aripiprazole and an exacerbation of Parkinsonism although this relationship is poorly defined. To our knowledge this is the first case series describing an onset of Parkinsonism in patients without prior history of Parkinson s disease following aripiprazole treatment. Case presentation We describe two patients ages 69 and 58 who developed cardinal features of Parkinson s disease shortly after receiving aripiprazole. Both patients were male veterans with a history of bipolar disorder treated with aripiprazole. They initially presented with asymmetric arm tremor and subsequently developed rigidity bradykinesia and postural instability. On examination they were found to be at a Hoehn and Yahr stage of for their Parkinsonism. Conclusions While aripiprazole has been associated with infrequent extrapyramidal side effects these cases raise concerns that