tailieunhanh - Báo cáo y học: " Analysis of IL-12 p40 subunit gene and IFN-γ G5644A polymorphisms in Idiopathic Pulmonary Fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Analysis of IL-12 p40 subunit gene and IFN-γ G5644A polymorphisms in Idiopathic Pulmonary Fibrosis | Respiratory Research BioMed Central Research Open Access Analysis of IL-12 p40 subunit gene and IFN-Y G5644A polymorphisms in Idiopathic Pulmonary Fibrosis Panagiota Latsi Panagiotis Pantelidis Dimitris Vassilakis Hiroe Sato Kenneth I Welsh and Roland M du Bois Address Interstitial Lung Disease Unit Department of Occupational and Environmental Medicine Imperial College National Heart and Lung Institute Royal Brompton Hospital London United Kingdom Email Panagiota Latsi - pepilats@ Panagiotis Pantelidis - Dimitris Vassilakis - dimvas@ Hiroe Sato - Kenneth I Welsh - Roland M du Bois - Corresponding author Published 27 June 2003 Received 29 May 2003 Accepted 27 June 2003 Respiratory Research 2003 4 6 This article is available from http content 4 1 6 2003 Latsi et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Genes encoding cytokine mediators are prime candidates for genetic analysis in conditions with T-helper Th cell disease driven imbalance. Idiopathic Pulmonary Fibrosis IPF is a predominantly Th2 mediated disease associated with a paucity of interferon-gamma IFN-y . The paucity of IFN-y may favor the development of progressive fibrosis in IPF. Interleukin-12 IL-12 plays a key role in inducing IFN-Y production. The aim of the current study was to assess whether the 1188 A C 3 UTR single nucleotide polymorphism SNP in the IL-12 p40 subunit gene which was recently found to be functional and the 5644 G A 3 UTR SNP of the IFN-Y gene were associated with susceptibility to IPF. Methods We investigated the allelic distribution in these loci in UK white Caucasoid subjects comprising 73 patients with IPF and 157 healthy .