tailieunhanh - Báo cáo y học: "HIV-1 Tat interacts with LIS1 protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 Tat interacts with LIS1 protein | Retrovirology BioMed Central Research Open Access HIV-1 Tat interacts with LISI protein Nicolas Epie1 2 Tatyana Ammosova1 Tamar Sapir4 Yaroslav Voloshin1 William S Lane5 Willie Turner2 Orly Reiner3 and Sergei Nekhai 1 3 Address 1Center for Sickle Cell Disease Howard University Washington DC 20059 USA 2Department of Microbiology Howard University College of Medicine 520 W Street . Washington DC 20059 USA 3Department of Biochemistry and Molecular Biology Howard University College of Medicine 520 W Street . Washington DC 20059 USA 4Department of Molecular Genetics The Weizmann Institute of Science 76100 Rehoboth Israel and 5Harvard Microchemistry Facility 16 Divinity Ave. Cambridge MA 02138 USA Email Nicolas Epie - nepie@ Tatyana Ammosova - tammosova@ Tamar Sapir - Yaroslav Voloshin - yvoloshin@ William S Lane - wlain@ Willie Turner - wturner@ Orly Reiner - Sergei Nekhai - snekhai@ Corresponding author Published 07 February 2005 Received 09 December 2004 Accepted 07 February 2005 Retrovirology 2005 2 6 doi 86 1742-4690-2-6 This article is available from http content 2 1 6 2005 Epie et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain CTD of RNA polymerase II RNAPII . Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis. Tat-induced apoptosis of T-cells is attributed in part to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that .