tailieunhanh - Báo cáo y học: " Open Access Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Open Access Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry | Respiratory Research BioMed Central Review Open Access Growth factor signaling in lung morphogenetic centers automaticity stereotypy and symmetry David Warburton Saverio Bellusci Pierre-Marie Del Moral Vesa Kaartinen Matt Lee Denise Tefft and Wei Shi Address Developmental Biology Program Childrens Hospital Los Angeles Research Institute and the Center for Craniofacial Molecular Biology Keck School of Medicine and School of Dentistry University of Southern California Email David Warburton - dwarburton@ Saverio Bellusci - sbellusci@ Pierre-Marie Del Moral - p_delmoral@ Vesa Kaartinen - vkaartinen@ Matt Lee - mattlee@ Denise Tefft - dtefft@ Wei Shi - wshi@ Corresponding author Published 19 June 2003 Received 29 July 2002 Accepted 17 February 2003 Respiratory Research 2003 4 5 This article is available from http content 4 1 5 2003 Warburton et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Lung morphogenesis is stereotypic both for lobation and for the first several generations of airways implying mechanistic control by a well conserved genetically hardwired developmental program. This program is not only directed by transcriptional factors and peptide growth factor signaling but also co-opts and is modulated by physical forces. Peptide growth factors signal within repeating epithelial-mesenchymal temporospatial patterns that constitute morphogenetic centers automatically directing millions of repetitive events during both stereotypic branching and nonstereotypic branching as well as alveolar surface expansion phases of lung development. Transduction of peptide growth factor signaling within these centers is finely regulated at multiple levels. These may include ligand .