tailieunhanh - Báo cáo y học: "Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report | JOURNAL OF MEDICAL Sr CASE REPORTS Open Access Case report Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital a case report Alice Liguori and Stefano Cianfarani Address Rina Balducci Center of Pediatric Endocrinology Department of Public Health and Cell Biology Tor Vergata University 00133-Rome Italy Email AL - aliceliguori@ SC - Corresponding author Received 19 February 2008 Accepted 23 January 2009 Published 12 June 2009 Journal ofMedical Case Reports 2009 3 7300 doi 1752-1947-3-7300 This article is available from http jmedicalcasereports article view 7300 2009 Liguori and Cianfarani licensee Cases Network Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Anticonvulsant drugs taken by pregnant women to prevent seizures are among the most common causes of potential harm to the fetus. While the immediate harmful effects manifesting as congenital abnormalities are well known the long-term effects on growth of children exposed in utero to antiepileptic drugs are still uncertain. Case presentation A 7-year-old boy presented to our clinic with severe short stature. His height was cm standard deviation score with a target height of 177 cm standard deviation score . Height corrected for target height was standard deviation score. He presented with mild dysmorphic facial features hypospadias and postnatal onset of severe growth retardation. Biochemical and endocrine tests were in the normal range. The child was exposed in utero to both carbamazepine and phenobarbital. Conclusion This case report shows for the first time that prenatal exposure to antiepileptic drugs may induce postnatal .