tailieunhanh - Báo cáo y học: "Situs inversus totalis and secondary biliary cirrhosis: a case report"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Situs inversus totalis and secondary biliary cirrhosis: a case report. | Sõkmen et al. Comparative Hepatology 2011 10 5 http content 10 1 5 COMPARATIVE HEPATOLOGY CASE REPORT Open Access Situs inversus totalis and secondary biliary cirrhosis a case report 11 1 1 2 1 Haci Mehmet Sokmen Kamil Ozdil Turan Ọalhan Abdurrahman Ẹahin Ebubekir Ẹenateị Resul Kahraman Adil Nigdelioglu1 and Ebru Zemheri3 Abstract Situs inversus totalis is is a congenital anomaly associated with various visceral abnormalities but there is no data about the relationship between secondary biliary cirrhosis and that condition. We here present a case of a 58 year-old female with situs inversus totalis who was admitted to our clinic with extrahepatic cholestasis. After excluding all potential causes of biliary cirrhosis secondary biliary cirrhosis was diagnosed based on the patient s history imaging techniques clinical and laboratory findings besides histolopathological findings. After treatment with tauroursodeoxycholic acid all biochemical parameters including total direct bilirubin alanine aminotransferase aspartate aminotransferase alkaline phosphatase and gama glutamyl transferase returned to normal ranges at the second month of the treatment. We think that this is the first case in literature that may indicate the development of secondary biliary cirrhosis in a patient with situs inversus totalis. In conclusion situs inversus should be considered as a rare cause of biliary cirrhosis in patients with situs inversus totalis which is presented with extrahepatic cholestasis. Keywords Situs inversus totalis secondary biliary cirrhosis tauroursodeoxycholic acid Background Situs inversus totalis SIT is a congenital anomaly characterized by complete transposition of abdominal and thoracic organs. As a birth defect in newborn infants it has an estimated incidence of 1 15000 to 10000 cases in live births with a male female ratio of 3 2. Generally this rare anomaly is diagnosed incidentally during thoracic and abdominal imaging. The cause of .