tailieunhanh - Báo cáo y học: " Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports | Journal of Medical Case Reports BioMed Central Open Access Case report Pityriasis rubra pilaris presenting with an abnormal autoimmune profile two case reports Stamatis Gregoriou 1 Zoe Chiolou2 Christina Stefanaki1 Niki Zakopoulou2 Dimitrios Rigopoulos1 and George Kontochristopoulos2 Address University of Athens Medical School Department of Dermatology Athens Greece and 22nd Department of Dermatology Andreas Sygros Hospital Athens Greece Email Stamatis Gregoriou - stamgreg@ Zoe Chiolou - chiolouz@ Christina Stefanaki - cstefana@ Niki Zakopoulou - zakonico@ Dimitrios Rigopoulos - drigop@ George Kontochristopoulos - gkontochristo@ Corresponding author Published 13 November 2009 Received 22 November 2008 _ _AAAO nn IA - - n- Accepted 13 November 2009 Journal of Medical Case Reports 2009 3 123 doi l 752-1947-3-123 This article is available from http content 3 1 123 2009 Gregoriou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown. Case presentation We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type l both patients also exhibited an abnormal immunological profile. Conclusion Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this