tailieunhanh - Báo cáo y học: " Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours. | van Sprundel et al. Comparative Hepatology 2010 9 4 http content 9 1 4 COMPARATIVE HEPATOLOGY RESEARCH Open Access Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours Renee GHM van Sprundel1 Ted SGAM van den Ingh2 Valeer J Desmet3 Azeam Katoonizadeh3 Louis C Penning1 Jan Rothuizen1 Tania Roskams3 Bart Spee1 3 Abstract Background The expression of Keratin 19 K19 was reported in a subset of hepatocellular carcinomas HCCs . K19 positive HCCs are associated with an increased malignancy compared to K19 negative HCCs. No suitable mouse models exist for this subtype of HCC nor is the incidence of K19 expression in hepatocellular neoplasia in model animals known. Therefore we compared the occurrence and tumour behaviour of K19 positive hepatocellular neoplasias in dog and man. Results The expression of hepatocellular differentiation HepPar-1 biliary progenitor cell K7 K19 and malignancy glypican-3 markers was semi-quantitatively assessed by immunohistochemistry. The histological grade of tumour differentiation was determined according to a modified classification of Edmondson and Steiner the staging included intrahepatic lymph node or distant metastases. Four of the 34 canine hepatocellular neoplasias showed K19 positivity 12 of which two co-expressed K7. K19 positive tumours did not express HepPar-1 despite the histological evidence of a hepatocellular origin. Like in human HCC all K19 positive hepatocellular neoplasias were glypican-3 positive and histologically poorly differentiated and revealed intra- or extrahepatic metastases whereas K19 negative hepatocellular neoplasias did not. Conclusions K19 positive hepatocellular neoplasias are highly comparable to man and occur in 12 of canine hepatocellular tumours and are associated with a poorly differentiated histology and aggressive tumour behaviour. Background Hepatic progenitor cells HPCs are activated in the majority of liver .