tailieunhanh - Báo cáo y học: "Relation between lipogranuloma formation and fibrosis, and the origin of brown pigments in lipogranuloma of the canine liver"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Relation between lipogranuloma formation and fibrosis, and the origin of brown pigments in lipogranuloma of the canine liver. | Comparative Hepatology BioMed Central Research Relation between lipogranuloma formation and fibrosis and the origin of brown pigments in lipogranuloma of the canine liver Kaori Isobe Hiroyuki Nakayama and Koji Uetsuka Address Department of Veterinary Pathology Graduate School of Agricultural and Life Sciences University of Tokyo Japan Email Kaori Isobe - born_to_see_you@ Hiroyuki Nakayama - anakaya@ Koji Uetsuka - akasata@ Corresponding author Open Access Published 12 May 2008 Received 20 February 2008 Comparative Hepatology 2008 7 5 doi 1476-5926-7-5 Accepted 12 May 2008 This article is available from http content 7 1 5 2008 Isobe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background In a previous study we confirmed that canine hepatic lipogranuloma defined as lesions consisting of small round cells which contain lipid vacuoles and brown pigments in their cytoplasm was an assembly of Kupffer cells and or macrophages and that the cytoplasmic brown pigments in the lesions were hemosiderin and ceroid. However the pathogenesis of the lesion remains unclear. Kupffer cells resident macrophages play a key role in hepatic fibrogenesis due to the production of cytokines including TGF-P. In the present study we have examined 52 canine liver samples age newborn - 14 years 25 males and 27 females and investigated the correlation between lipogranuloma formation and fibrosis as well as the origin of brown pigments of lipogranulomas. Results Lipogranulomas were detected histopathologically in 23 of the 52 liver samples. No significant .