tailieunhanh - Báo cáo y học: "Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damage. | Comparative Hepatology BioMed Central Open Access Case Report Over-expression of glutamine synthase in focal nodular hyperplasia part 1 Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous portal and hepatic and biliary damage Paulette Bioulac-Sage1 2 Hervé Laumonier3 Gaelle Cubel2 Jean Saric4 and Charles Balabaud 2 4 Address 1Service d Anatomie Pathologique Hôpital Pellegrin CHU Bordeaux France 2GREF Inserm U889 Université Bordeaux 2 France 3Service de Radiologie Hôpital Saint André CHU Bordeaux France and 4Pôle HGE Hôpital Saint André CHU Bordeaux France Email Paulette Bioulac-Sage - Hervé Gaelle Cubel - cubel@ Jean Charles Balabaud - Corresponding author Published 29 February 2008 Received 19 October 2007 Comparative Hepatology 2008 7 2 doi 1476-5926-7-2 Accepted 29 February 2008 This article is available from http content 7 1 2 2008 Bioulac-Sage et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Most focal nodular hyperplasia FNH cases are diagnosed by chance. We studied a case of pre-FNH. We used glutamine synthase as an immunohistochemical marker for perivenous zones. Results Neither fibrotic scars nor hepatocytic nodules surrounded by fibrosis with a ductular reaction were observed in the sections studied. Most sections generally displayed preserved architecture. The glutamine synthase-positive hepatocyte areas were wider than those observed in non-tumoural surrounding liver and they tended to extend outwards. Portal tracts bordering the nodule .