tailieunhanh - Báo cáo y học: "Persistent orocutaneous and anal fistulae induced by nicorandil: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Persistent orocutaneous and anal fistulae induced by nicorandil: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Persistent orocutaneous and anal fistulae induced by nicorandil a case report Cyndi Goh Sally CY Wong and Colin Borland Address Department of Medicine Hinchingbrooke Hospital Hinchingbrooke Heath Care NHS Trust Huntingdon Cambridgeshire PE29 6NT UK Email Cyndi Goh - Sally CY Wong - scywong@ Colin Borland - Corresponding author Published 12 November 2009 Received 26 February 2008 _ r- n inAO J. .IA I lozmri IIO Accepted 12 November 2009 Journal of Medical Case Reports 2009 3 119 doi I86 I752-I947-3-II9 This article is available from http content 3 I I I9 2009 Goh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Although nicorandil is prescribed widely awareness of its potential to cause serious complications to the gastrointestinal tract mucosa is limited. Whilst nicorandil-induced oral and anal ulceration is well documented in the literature nicorandil-induced fistulation is not. This is the first report in the literature of a single patient demonstrating simultaneous orocutaneous and anal fistulae during nicorandil therapy. Two separate cases of orocutaneous and anal fistulae associated nicorandil usage have previously been documented in specialist journals. Case presentation A 7I-year-old Caucasian man presented with a 3-year history of concurrent orocutaneous and anal fistulae. He had been exposed to 30 mg twice-daily nicorandil therapy for 4 years. Both fistulae responded poorly to intensive and prolonged conventional treatment but healed promptly on reduction and eventual withdrawal of nicorandil therapy. .