tailieunhanh - Báo cáo y học: " Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case report. | Journal of Medical Case Reports BioMed Central Open Access Case report Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B a case report Sabrina Bagaglio1 Luca Albarello2 Priscilla Biswas1 Caterina Uberti-Foppa1 Claudio Fortis1 and Giulia Morsica 1 Address infectious Diseases Department San Raffaele Scientific Institute Via Stamira d Ancona Milano 20127 Italy and 2Division of Pathology San Raffaele Scientific Institute Via Olgettina Milano 20132 Italy Email Sabrina Bagaglio - Luca Albarello - Priscilla Biswas - Caterina Uberti-Foppa - Claudio Fortis - Giulia Morsica - Corresponding author Published 9 November 2009 Received 5 June 2008 Journal of Medical Case Reports 2009 3 110 doi 1752-1947-3-110 Accepted 9 November 2009 This article is available from http content 3 1 1 10 2009 Bagaglio et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction There seem to be no published data concerning the clinical impact of populations of hepatitis B virus HBV in the hepatic and extrahepatic compartments of HIV-infected people with severe acute hepatitis. Case presentation A 26-year-old Caucasian man presenting to our hospital with clinical symptoms suggesting acute hepatitis was found to have an acute hepatitis B profile upon admission. He developed fatal fulminant hepatitis and was found to be heavily immunocompromised due to HIV-1 infection. He had a high plasma HBV and HIV load and analysis of the partial pre-S1 pre-S2 domain showed the presence of mixed infection with D and F genotypes. Analysis