tailieunhanh - Báo cáo y học: " HTLV-1 and -2 envelope SU subdomains and critical determinants in receptor binding"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HTLV-1 and -2 envelope SU subdomains and critical determinants in receptor binding | Retrovirology BioMed Central Research Open Access HTLV-I and -2 envelope SU subdomains and critical determinants in receptor binding Felix J Kim1 2 Nicolas Manel1 Edith N Garrido1 Carine Valle1 Marc Sitbon 1 and Jean-Luc Battini 1 Address 1Institut de Génétique Moléculaire de Montpellier IGMM CNRS-UMR5535 IFR122 1919 Rte de Mende F-34293 Montpellier Cedex 5 France and 2Current address Memorial Sloan-Kettering Cancer Center 1275 York Ave New York NY 10021 USA Email FelixJ Kim - kimf@ Nicolas Manel - manel@ Edith N Garrido - edith@ Carine Valle - vallecarine@ Marc Sitbon - sitbon@ Jean-Luc Battini - battini@ Corresponding authors Published 02 December 2004 Received 13 September 2004 Accepted 02 December 2004 Retrovirology 2004 1 41 doi 1742-4690-1-41 This article is available from http content 1 1 41 2004 Kim et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukemia virus HTLV -1 and -2 are deltaretroviruses that infect a wide range of cells. Glut1 the major vertebrate glucose transporter has been shown to be the HTLV Env receptor. While it is well established that the extracellular surface component SU of the HTLV envelope glycoprotein Env harbors all of the determinants of interaction with the receptor identification of SU subdomains that are necessary and sufficient for interaction with the receptor as well as critical amino acids therein remain to be precisely defined. Although highly divergent in the rest of their genomes HTLV and murine leukemia virus MLV Env appear to be related and based on homologous motifs between the HTLV and MLV SU we derived chimeric HTLV MLV Env and soluble