tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 143

Pharmaceutical Substances Syntheses, Patents, Applications - Part 143. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Nevirapine N 1421 nh2 sisomicin q- V. 1. H2SO4 pH 5 2. HjC CHO 3. NaBHjCN 2. acetaldehyde 3. sodium cyano-borohydride from 1 -N-ethyl-a-deoxy-D -streptomin by fermentation with Micromonospora inyoensîs 1550F-1C Reference s DOS 2 462 485 Scherico appl. USA-prior. . DOS 2 437 160 Scherico appl. USA-prior. - also further methods . US 4 002 742 Scherico prior. . Formulation s amp. 15 mg ml 50 mg ml 100 mg ml 150 mg ml 200 mg 2 ml as sulfate Trade Name s D Certomycin Essex Pharma 1980 GB Netillin Schering-Plough 1981 J Netilyn Sankyo 1985 Vectacin Essex F Netromicine Schering- I Nettacin Schering-Plough USA Netromycin Schering Plough 1983 1982 1983 Zetamicin Menarini 1982 Nevirapine BI-RG-587 ATC J05AG01 Use antiviral anti-AIDS therapeutic reverse transcriptase inhibitor RN 129618-40-2 MF C15H14N4O MW CN ll-cyclopropyl-5 ll-dihydro-4-methyl-6 -dipyrido 3 2-b 2 3 -e l 4 diazepin-6-one HO O2N ch3 2- hydroxy- 3- nitro-4-methylpyridine PCI5 POCỊ 2-chloro-3-nitro-4-me- thyl pyridine SnCI4 CH3COOH CHj 3-omino-2-chloro-4-me-thylpyrîdine I 1422 N Nevirapine cyclohexane ------------ xylene 165 C -------------- IV cyclapropyl-cmine III 2-chlaro-nicotinoyl chloride H 2- chloro-N- 2-chloro-4-methyl- 3- pyridinyl -3-pyri-dinecorboxamide N- 2-chlora--4-methyl-3-pyridyl -2-cyclpra-pylamino-3-pyridine -carboxamide IV Nevirapine Yj h2n H3C ch3 o o h3c CH3 2-methoxy-3- di-tert-butyl aminopyridine dicarbonate H3CvCH3 h3c o n 3- tert-t utoxy-carbonylomino -2-methoxy-pyridine V V 4- H3C I 1. BuLi Et2O 2. HCI. EtOAc 2-chloro-N- 2- 3-omino-2-methaxy-4-methylpyridine methoxy-4-methyl-3-pyridinyl -3-pyridinecorbax-amide VI V H3 HjC Si-N -SiCCH Na- - Nevirapine cyanoacetamide ethyl ocetoacetate 2 6-dichlor0-4-methyl-3-pyridine-carbonitrile VII Nialamide N 1423 H2SO4 150-170 C VII ----------- NaOH Br2 2 6-dichloro-4-methyl-3-pyridine-carboxomide 3-amino-2 6-dichloro-4-methyl pyridine cyclohexane ------------- .