tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 138

Pharmaceutical Substances Syntheses, Patents, Applications - Part 138. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Moxestrol M 1371 H3C O X CHO no2 xCH3 NaOCH3 N02 h3c OH 3 4-dimethoxy- 1-nitro- benzoldehyde propane 1 - 3 4-dimethoxy-phenyl -2-nitro- 1-butanal I --------------------- II phenylacetyl chloride 2-omino-1- 3 4-dimethoxyphenyl -1 - butanol Reference s GB 1 030 022 Orgamol appl. CH-prior. . Formulation s amp. 150 mg 5 ml drg. 100 mg 150 mg as hydrochloride Trade Name s D Certonal Sertürner Kallaterol Ursapharm -comb. Kollateral Ursapharm I Eupaverina Bracco wfm Moxestrol ATC G03CB04 Use estrogen RN 34816-55-2 MF C21H26O3 MW CN llß 17a -l l-methoxy-19-norpregna-l 3 5 10 -trien-20-yne-3 17-diol 3 17-dîoxo-11 3-hydroxy-4 9-estrodiene H3C OH 1372 M Moxifloxacin hydrochloride i HC CH acetylene potassium tertamylate Reference s US 3 579 545 Roussel-Uclaf F-prior. . FR-M 6 182 Roussel-Uclaf appl. . Azadian-Boulanger G. Berlin D. Chim. Ther. CHTPBA 8 451 1973 . starting material Joly R. et al. C. R. Seances Acad. Sci. Ser. C CHDCAQ 258 5669 1964 total synthesis . Formulation s tabl. 50 pg Trade Name s F Surestryl Roussel-Uclaf Moxifloxacin hydrochloride Bay-12-8039 ATC J01MA14 Use fluoroquinolone antibacterial RN 186826-86-8 MF C21H24FN3O4 HC1 MW CN l-Cyclopropyl-6-fluoro-l 4-dihydro-8-methoxy-7- 4aS 7aS -octahydro-6H-pyrrolo 3 4-i pyridin-6-yl -4-oxo-3-quinolinecarboxylic acid base RN 151096-09-2 MF C H FNjQ MW c in COOH ------------ benzylamine 1 pyridine-2 3-dicarbaxylic acid -cis-8-benzyl- 2 8-diazabicyclo- nonane -n 1. L- -tartaric acid DMF 2. crystallization 3. mother liquors NaOH 4. D- -tartaric acid crystallization 5. NaOH ----------------------------------------k -II Moxifloxacin hydrochloride M 1373 H2. Pd-C ------- -II S S -2 8-diaza- bicyclo nonone UI N c2h5 3 --------- 0 0 0 0 2 4 5-trifluoro- 3-methoxybenzoyl chloride IV potassium monoethyl malonote ethyl 2- 2 4 5-trifluoro- 3-methoxybenzoyl acetate V .CH 0 . TY i rAAAzC c h r n n Y nh2 .