tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 122

Pharmaceutical Substances Syntheses, Patents, Applications - Part 122. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Mebendazole M 1211 2- 4-chlorobenzoyl -benzoic acid h2n. H2tv ethylene- diamine Tos OH -------- HnSO 4 -chlora-2- 2-imidazolin- 2-yl -benzo- phenane NaOH ------ Reference s DOS 1 770 030 Sandoz appl. USA-prior. . US 3 597 445 Sandoz-Wander appl. . US 3 763 178 American Home Products appl. prior. . alternative syntheses DOS 1 795 105 Sandoz appl. USA-prior. . DOS 1 814 540 Sandoz appl. USA-prior. . DOS 1 930 488 Sandoz appl. USA-prior. . Formulation s tabl. 1 mg 2 mg Trade Name s . D Teronac Wander wfm I Mazildene Lifepharma USA Sanorex Sandoz wfm GB Teronac Wander wfm wfm Mebendazole ATC P02CA01 Use anthelmintic RN 31431-39-7 MF C16H13N3O3 MW EINECS 250-635-4 LDS0 620 mg kg M . 714 mg kg R . 1280 mg kg dog . CN 5-benzoyl-l -benzimidazol-2-yl carbamic acid meth ester 1212 M Mebeverine 4-chloro-benzophenone HNOj - 5 C 0 4-chloro-3-nitro-benzophenone NHj CHjOH sulfolone 125 C -------------------k i 4-amino-3-nitro- benzophenone I H2 Pd-C 0 3 4-diamtno-benzophenone II h2so4 0 n ch 0 3 NoOH. pH 8 ------------- S__NH H cr h 2 n xh o 3 Y J NH S-methylthiouronlum- methyl sulfate chloroformote methyl S-methyl-isothiourea-N-corboxylate III II III CHjCOONa Mebendazole Reference s DE 2 029 637 Janssen appl. USA-prior. . US 3 657 267 Janssen prior. . Formulation s chewable tabl. 100 mg susp. 100 mg 5 ml tabl. 100 mg 500 mg Trade Name s D Surfont Ardeypharm GB Vermox Janssen-Cilag J Mebendazol Janssen Vermox Janssen-Cilag 1976 Kyowa 1976 I Vermox Janssen 1979 USA Vermox Janssen 1975 Mebeverine atc A03AA04 Use antispasmodic RN 3625-06-7 MF C25H35NO5 MW EINECS 222-830-4 LD50 24 mg kg M . 995 mg kg M . CN 3 4-dimethoxybenzoic acid 4- ethyl 2- 4-methoxyphenyl -l-methylethyl amino butyl ester hydrochloride RN 2753-45-9 MF C H NO HC1 MW EINECS .