tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 116

Pharmaceutical Substances Syntheses, Patents, Applications - Part 116. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Lercanidipine hydrochloride L 1151 Reference s US 3 883 505 Ajinomoto J-prior. . DE 2 336 378 Ajinomoto appl. J-prior. . Chibara J. et al. Cancer Res. CNREA8 30 2776 1970 . Chihara G. et al. Nature London NATUAS 222 637 1968 . structural study Sasaki T. et al. Carbohydr. Res. CRBRAT 47 99 1976 . water soluble pharmaceutical formulation US 4 207 312 Ajinomoto Morishita J-prior. . combination with CSF EP 326 149 Green Cross Morinaga appl. J-prior. . Formulation s vial 1 g Trade Narne s J Lentinan Ajinomoto- Morishita Yamanouchi 1986 Lercanidipine hydrochloride ATC CO8CA13 Use treatment of hypertension vasoselective calcium antagonist RN 132866-11-6 MF C36H4 N3O6 HC1 MW CN l 4-Dihydro-2 6-dimethyl-4- 3-nitrophenyl -3 5-pyridinedicarboxylic acid 2- 3 3-diphenylpropyl methylamino -1 1 -dimethylethyl methyl ester hydrochloride base RN 100427-26-7 MF C36H41N3O6 MW HCHO o HCI H2O ------------- 3- benzylmethyl-amino - 1-phenyl-propan-1-one I acetophenone form- methylbenzyl- aldehyde amine 1152 L Lercanidipine hydrochloride phenyl-mognesium bromide 3- benzylmethylamino - H2 Pd-C c2hsoh H ---------- 3 3-diphenyl-N-methylpropylamine ll 1 -propanol xylene A ---------- 1 -chloro- 2-methyl- 2-propanol 1 - 3 3-diphenyl-N-methylpropylamino -2-methyl-2-propanol III VI 3-nttro-benzaldehyde V 2. HCI H2O VI ----------------------------- 1. methyl 3-amino-crotanate VII tert-butyl 2- 3-nitro-benzylidene acetoacetote VII ------ VIII tert-butyl acetoacetote Letosteine L 1153 5-tert-butyl 3-methyl 2 6-dimethyl-4- 3-nitro-phenyl -1 4-dihydro-pyridine-3 5-dicarboxylate VUI 2 6-dimethyl-5-methoxycarbonyl-4- 3-nitrophenyl -1 4-dihydropyridine- 3-carboxylic acid Reference s Leonard A. et al. Eur. J. Med. Chem. EJMCA5 33 399 1998 . a EP 153 016 Recordati Chem. and Pharm. appl. GB-prior. . b WO 9 635 668 Recordati Chem. and Pharm. appl. I-prior. . preparation of 3- .

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