tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 92

Pharmaceutical Substances Syntheses, Patents, Applications - Part 92. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Flurbiprofen F 911 HBr ------ dichloro- 5 6 dicyano- benzoquinone Reference s US 3 567 710 Hoffmann-La Roche prior. . alternative synthesis by reaction q 2-diethylaminoethyl chloride with 7-chloro-5- 2-fluorophenyl -2-oxo-2 3-dihydro- IH-1 4-benzodiazepine GB 1 040 548 Roche appl. USA-prior. . Formulation s cps. 10 mg 15 mg tabl. mg as base cps. 15 mg 30 mg tabl. 30 mg as monohydrochloride cps. 15 mg 30 mg s. r. cps. 20 mg as dihydrochloride Trade Name s D Dalmadorm Roche Flurazepam 15 30 Riker 3M Medica Staurodorm Neu Dolorgiet GB Dalmane Roche I Dalmadorm Roche Felison Bayropharm Flunox Boehringer Mannh. Midorm . Piam Remdue Biomedica Foscama Valdorm Valeas J Benozil Kyowa Dal mate Nippon Roche Insumin Kyorin USA Dalmane Roche Flurbiprofen ATC M01AE09 M02AA19 S01BC04 Use anti-inflammatory analgesic RN 5104-49-4 MF C15H13FO2 MW EINECS 225-827-6 LD50 385 mg kg M . 640 mg kg M . 117 mg kg R . 10 mg kg dog . CN 2-fluoro-a-methyl l 1 -biphenyl -4-acetic acid sodium salt RN 56767-76-1 MF C15H12FNaO2 MW bromobenzene 4 -bromo-3 -nitfoocetophenone 0 SnCI2 4-acetyl-2-nitra-biphenyl 1. NaNO2 2. HBF4 1 4-acetyl-2-omino-biphenyl 912 F Flurbiprofen 1 s HIV 0 2. H2SOt 2-fluoro-4-biphe-nylylocetic ocid ethyl 2-fluoro-4-biphenylylocetote II diethyl corbonate 1. NoOC2H5 2. HjC ks P O xo CH3 -------------------- 2. dimethyl sulfote 4-brorno-2-fluorobiphenyl H CYU ONa ----2---------- sodium pyruvate 2-hydroxypropionic acid III polyphosphoric ocid 2- 2-fluoro-4-bi-phenylyl acrylic acid Flurbiprofen Reference s a DAS 1 518 528 Boots appl. GB-prior. . US 3 755 427 Boots GB-prior. . US 3 793 457 Adams Sectal GB-prior. . b GB 1 514 812 Boots appl. valid from . similar method US 3 959 364 Boots GB-prior. . alternative syntheses DOS 2 646 792 Mitsubishi Petrochemical appl. J-prior.

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