tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 18

Pharmaceutical Substances Syntheses, Patents, Applications - Part 18. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Aztreonam A 171 1. CISOjH 2-picoline CH2CI2 2. V CH2CI2 ------------------------------ N1-sulfo-N2-benzyloxycorbonyl-O-methylsulfonyl-L-threoninamide tetrabutylammonium salt XII VIII K2CO3 C2H CI2 H2O M2 Pd-C C2H50H N-hydroxybenzotriazole DCC xn----------- -------------V ---------------- ----------- VII ---------------------------------- IX anisole. CFjCOOH -------- I------------ Aztreonam Reference s US 4 386 034 Squibb prior. . US4529 698 Squibb prior. . US 4 625 022 Squibb prior. . DOS 3 104 145 Squibb appl. USA-prior. . GB 2 071 650 Squibb appl. USA-prior. . Formulations amp. 2 g inj. powder 500 mg 1 g 2 g lyo. for inf. 2 g vial 1 g 3 nil Trade Name s D Azactam Bristol-Myers GB Azactam Bristol-Myers J Azactam Squibb 1987 Squibb 1985 Squibb 1986 USA Azactam Bristol-Myers F Azactam Sanofi Winthrop I Azactam Squibb 1984 Squibb 1987 172 B Bacampicillin Bacampicillin atc joicaoö Use antibiotic broad spectrum penicillin RN 50972-17-3 MF C21H27N3O7S MW CN 2S- 2a 5a 6ß S -6- aminophenylacetyl amino -3 3-dimethyl-7-oxo-4-thia-1 -azabicyclo heptane-2-carboxylic acid l- ethoxycarbonyl oxy ethyl ester monohydrochloride RN 37661-08-8 MF C21H27N3O7S HCl MW EINECS 253-580-4 LD50 184 mg kg M . 8529 mg kg M . 176 mg kg R . 10 g kg R . CH30 dmf azidocillin sodium salt 1-chloroethyl q. V. ethyl carbonote 6- D-a-azidaphenylacetamido -penicillanic acid 1-ethoxycarbonyloxyethyl ester 1 Reference s DAS 2 144457 Astra appl. S-prior. . US 3 873 521 Astra S-prior. . US 3 939 270 Astra S-prior. . Formulation s f. c. tabl. 400 g 800 mg susp. 125 mg as hydrochloride Trade Name s D Ambacamp Pharmacia Penglobe Lematte et Bacacil Pfizer Upjohn 1981 Boinot Penglobe Bracco Penglobe Astra 1977 GB Ambaxin Upjohn 1980 J Bacacil Pfizer Taito F Bacampicine Pharmacia I .

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