tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 17

Pharmaceutical Substances Syntheses, Patents, Applications - Part 17. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Azelastine A 161 alternative synthesis US 3 402 108 Emery appl. . US 3 810 937 . Kuceski appl. . JP 56 169 640 Nippon Oil appl. . JP 58 140 038 Kuraray appl. . DOS 2 035 558 Degussa appl. . DOS 2 052 815 Degussa appl. . DOS 2 106 307 Degussa appl. . DOS 2 106 913 Degussa appl. . DOS 2 316 203 Henkel appl. . topical treatment US 4 818 768 Schering AG appl. I-prior. . Formulation s cream 200 mg g 20 Trade Nanie s D Skinoren Schering 1988 GB Skinoren Schering Health USA Azelex Allergan F Skinoren Schering Care Azelastine ATC R01AC03 R03D R06AX19 S01GX07 Use antiasthmatic antiallergic antihistaminic RN 58581-89-8 MF C H MW LD50 36 mg kg R . 130 mg kg R . CN 4- 4-chlorophenyl methyl -2- hexahydro-l-methyl-l -azepin-4-yl -l 2H -phthalazinone hydrochloride RN 37932-96-0 MF C22H24C1N3O xHCl MW unspecified EINECS 253-720-4 3- 4-chlorobenzylidene -phtholide 1. NoOH 2. HCI 2- 4-chlorophenyl-acetyl benzoic acid 1 Pn-CHj HCI 2H3C Na X 3 ------------ HOOC N hci -------------------------------- 0 H 1. ethyl acrylote 2. sodium ethylate 1- methyl- 4-methylominobutyric pyrrolidin- acid hydrochloride 2- one W CHj 162 A Azidamfenicol koc ch3 3 II ----------------- potassium tert-butylate 1 -methylhexahydro-azepín-4-one 2. NaBH4 1. benzoylhydrazine 2. sodium borohydride CH í N HN X 7 0 1 -benzoyl-2- hexahydro-1 -methyl- azepin-4-yl - hydrazine III Reference s DE 2 164 058 ASTA-Werke appl. . US 3 813 384 ASTA-Werke CH-prior. . EP 316 633 ASTA Medica AG appl. D-prior. . Formulation s f. c. tabl. 1 mg 2 mg 4 mg nasal spray as hydrochloride mg puff Trade Name s D Allergodil ASTA Medica 1992 F Radetazin Arzneimittelwerk Dresden 1992 Allergodil ASTA Medica GB Rhinolast ASTA Medica 1991 J Azeptin Eisai 1986 USA Astelin Wallace Azidamfenicol Azidoamphenicol ATC