tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 16

Pharmaceutical Substances Syntheses, Patents, Applications - Part 16. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Atropine A 151 ocryloyl pentane- tetrahydfopapaverine I chloride 1 5-diol I methyl benzene- sulfonate Reference s DOS 2 655 883 Wellcome appl. GB-prior. . US 4 179 507 Wellcome GB-prior. . Stenkale . et al. Eur. J. Med. Chem. EJMCA5 16 515 1981 . Formulation s amp. 25 mg ml 50 mg 5 ml Trade Name s D Tracrium Glaxo Wellcome 1987 F Tracrium Glaxo Wellcome GB Tracrium Wellcome 1982 I Tracrium Wellcome USA Tracrium Glaxo Wellcome 1983 Atropine DL-Hyoscyamine ATC A03BA01 S01FA01 Use anticholinergic mydriatic antispasmodic RN 51-55-8 MF C1 Hi3NO3 MW EINECS 200-104-8 LD50 30 mg kg M . 75 mg kg M . 73 mg kg R . 500 mg kg R . CN e ỉófo- -a- hydroxymethyl benzeneacetic acid 8-methyl-8-azabicyclo oct-3-yl ester 152 A Atropine methonitrate borate 1 1 RN 51460-78-7 MF CI7H23NO3 H3BO3 MW sulfate 2 1 RN 55-48-1 MF C17H23NO3 1 2H2SO4 MW EINECS 200-235-0 LD5 31 mg kg M . 468 mg kg M . 37 mg kg R . 600 mg kg R . 60 mg kg dog . By extraction of Solanacean drugs especially Atropa belladonna Hyoscyamus niger or other species. On careful extraction L-hyoscyamine is obtained first which can be racemized to atropine by addition of alkali in ethanolic solution. Reference s Ullmanns Encykl. Tech. Chem. 3. AufL Vol. 3 201 f. Ullmanns Encykl. Tech. Chem. 4. Aufl. Vol. 7 151. Formulation s amp. for inj. 100 mg eye drops 10 mg inj. sol. mg mg 1 mg 2 mg tabl. mg Trade Name s Angiocardyl Rhenomed Chibro-Atropine Merck generics Farmigea Scfm Atropin in der Ophtiole Sharp Dohme-Chibret and combination Mann generics and numerous preparations Atropinol Augentropfen combination preparations J generics Winzer GB Lomotil Searle -comb. USA Arco-Lase Plus Arco Atropin POS Ursapharm I Atropina Aolfato Scfm Atrohist Plus Medeva Borotropin Augentropfen Atropina Lux Allergan as Bellatal Richwood Winzer sulfate Donnatal Robins Cansat Sanofi Winthrop Atropi S Formulario Naz.