tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 11

Pharmaceutical Substances Syntheses, Patents, Applications - Part 11. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Amobarbital A 101 Amobarbital Amylobarbitone ATC N05CA02 Use hypnotic RN 57-43-2 MF MW EINECS 200-330-7 LD50 345 mg kg M . 250 mg kg R . 58 mg kg dog . CN 5-ethyL5- 3-methylbutyl -2 4 6 17 3H 5 7 -pyrimidinetrione monosodium salt RN 64-43-7 MF C Hl7N2NaO3 MW EINECS 200-584-9 LD50 505 mg kg M . 128 mg kg R . 275 mg kg R . 75 mg kg dog . 99 mg kg dog . v 0 diethyl molonate 1. NaOCzH5 2. H3C Br ethyl bromide diethyl ethylmalonate CH3 No0C2H5 j isopentyl bromide U H2N 7 4H2 NaOC2H5 --------------------- urea diethyl a-ethyl-a-isopentylmalonate I Reference s GB 191 008 E. Layraud 1922 F-prior. 1921 . US 1 856 792 Eli Lilly 1932 prior. 1929 . Formulation s tabl. 15 mg 30 mg 50 mg 100 mg Trade Name s D Ansudoral Basotherm - Meteoxane Gallier - GB Amytal Flynn comb. wfm . comb. wfm Sodium Amytal Flynn Jalonac Rohm Pharma - Nardyl Vemin -comb. Tuinal Flynn -comb. comb. wfm wfm 1 Amobarb Tariff. Metrotonin Temmler - Noctadiol Millot-Solac - Integrativo comb. wfm comb. wfm J Amytal Yamanouchi Stadadorm Tabl. Stada Supponoctal Houde - Isomytal Nippon wfm comb. wfm Shinyaku F Binoctal Houde -comb. Tcnsophoril Synlab - USA Amytal Lilly wfm comb. wfm Amytal Sodium Lilly Carlytene amobarbital Visceralgine comprimes Tuinal Lilly Dedieu -comb. wfm Riom -comb. wfm 102 A Amodiaquine Amodiaquine ATC P01BA06 Use antimalarial RN 86-42-0 MF C20H22ClN3O MW EINECS 201-669-3 LD5 550 mg kg M . CN 4- 7-chloro-4-quinolinyl amino -2- diethylamino methyl phenol dihydrochloride dihydrate RN 69-44-3 MF C20H22ClN3O 2HC1 2H2O MW EINECS 200-706-0 7-chloro-4- 4-hydroxy-phenylamino quinoline I 4 7-dichloro- quinoline cf. chloroquine synthesis 4-ominophenol I HCH0 HN CH- k CH3 formaldehyde diethylamine Reference s US 2 474 821 Parke Davis 1949 prior. 1945 . Burckhalter . et al. J. Am. Chem. Soc. JACSAT 68 1894 1946 . Formal at louis tabl. 200 mg as dihydrochloride dihydrate Trade Namds F Flavoquine Roussel GB Camoquin Parke Davis USA Camoquin .