tailieunhanh - Pharmaceutical Substances Syntheses, Patents, Applications - Part 58

Pharmaceutical Substances Syntheses, Patents, Applications - Part 58. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Dacarbazine D 571 Dacarbazine DTIC ATC L01XX13 Use antineoplastic RN 4342-03-4 MF C6H10N6O MW EINECS 224-396-1 LDS0 466 mg kg M . 2032 mg kg M . 411 mg kg R . 2147 mg kg R . CN 5- 3 3-dimethyl-l-triazenyl -l -imidazole-4-carboxamide 5-omino-îmîdazole-4-corboxomide NaN02 H2SO4 4- carbamoyl- 5- diazonîo-bP-imidazolide Çh3 NH CHjOH ----------- CH H H3Cx N N H2N O Dacarbazine Reference s Shealy . et al. J. Org. Chem. JOCEAH 27 2150 1962 . Formulation s lyo. 100 mg 200 Trade Name s D Detimedac medac . 100 200 Rhone- Poulenc F Deticene Rhóne-Poulenc Rorer Bellon GB DTIC-DOME Bayer I Deticene Rhône-Poulenc Rorer J Dacarbazine Kyowa Hakko USA DTIC-DOME Bayer Dactinomycin Actinomycin D Meractinomycin ATC L01DA01 Use antibiotic antineoplastic RN 50-76-0 MF C62H86N12O16 MW EINECS 200-063-6 LDS0 1025 pg kg M . 13 mg kg M . 460 pg kg R . 7200 pg kg R . CN stereoisomer of V A- 2-amino-4 6-dimethyl-3-oxo-3 -phenoxazine-l 9-diyl bis carbonylimino 2- l-hydroxyethyl -1 -oxo-2 1 -ethanediyl imino 2- 1 -methylethyl -1 -oxo-2 1 -ethanediyl -1 2-pyrrolidinediylcarbonyl methylimino 1 -oxo-2 1 -ethanediyl bis V-methyl-L-valine di- -lactone Danazol 572 D From cultures of Actinomyces antibioticus and chromatographic purification on A12O3. Reference s US 2 378 876 Merck Co. 1945 appl. 1941 . Formulation s lyo. mg Trade Name s D Lyovac Merck Sharp Doh me GB Cosmegen Lyovac Merck Sharp Dohme I Cosmegen Merck Sharp Dohme USA Cosmegen Merck Sharp Dohme Danazol ATC G03XA01 Use antigonadotropin anterior pituitary suppressant RN 17230-88-5 MF C22H27NO2 MW E1NECS 241-270-1 LD50 4830 mg kg M . 17 g kg R . 5 g kg dog . CN 17a -pregna 2 4-dien-20 yno 2 3-ii isoxazol-17-ol 17 -ethynyl-1 70-hydroxy-3-0X0-4-androstene ethyl formate JF Dantrolene D 573 H2N-OH Na-OCOCHj CHjCOOH Reference s GB 905 844 Sterling Drug valid from 1959 USA-prior. 1958 . US 3 135 743 Sterling Drug prior. . Piricle . et al. J. Med.

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