tailieunhanh - ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway

The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resistance. 5-Fluoro-uracil (5-FU) is the best-known chemotherapeutic drug for CC, but drug resistance affects its curative effect. |

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