tailieunhanh - Nghiên cứu quá trình giải phóng curcumin từ vi nang trong môi trường hỗng tràng giả lập

Bài viết trình bày nghiên cứu quá trình giải phóng curcumin từ vi nang trong môi trường hỗng tràng giả lập; Đánh giá quá trình giải phóng curcumin trong môi trường hỗng tràng giả lập của ruột non PBS pH = 6,4. | TNU Journal of Science and Technology 228 05 53 - 60 STUDY ON THE RELEASE OF CURCUMIN FROM THE MICRO BEAD IN THE SIMULATED JEJUNUM FLUID Tu Quang Tan Nguyen Duc Hung TNU University of Education ARTICLE INFO ABSTRACT Received 07 11 2022 Curcumin is a natural polyphenol isolated from the rhizomes of some plants of the Zingiberaceae family. Various studies suggest that curcumin is associated Revised 30 01 2023 with a number of biological activities including anti-inflammatory anti-cancer Published 31 01 2023 anti-oxidative anti-diabet and anti-microbial. However the bioavailability of curcumin is still faced difficulties because of its poor water solubility low chemical instability and low oral bioavailability related to its poor adsorption KEYWORDS and low metabolism in gastrointestinal tract. In the previous study the micro Curcumin curcumin beads S0 S3 S8 S15 were obtained by the ionotropic gelation method. The release of curcumin from micro curcumin beads in gastrointestinal Micro bead tract was further evaluated in simulated digestive fluids PBS pH and Release intestinal medium PBS pH . In order to complete the evaluation of release Simulated jejunum fluid of curcumin from micro curcumin beads in gastrointestinal tract this study was continued to evaluate the release of curcumin from micro curcumin beads in Kinetic mechanism simulated jejunum fluid PBS pH . The surfactant TPGS 3 g L was added to achieve the quot sink quot condition in the dissolution medium. The result showed that curcumin was released from micro curcumin beads S0 S3 S8 S15 during 420 minutes of release process and the release following to the Korsmeyer-Peppas model. Therefore the use of curcumin microcapsules has a potential application in controlling curcumin release in the gastrointestinal tract and targeting curcumin release in the jejunum of the small intestine. NGHIÊN CỨU QUÁ TRÌNH GIẢI PHÓNG CURCUMIN TỪ VI NANG TRONG MÔI TRƯỜNG HỖNG TRÀNG GIẢ LẬP Từ Quang Tân Nguyễn Đức Hùng .